Tissues and Biomaterial Research Group-(TBRG)Journal of Bioengineering Research2645-56331220190601Gold Nanorods Protected with Thiol-end Capped Diblock Copolymer (PHEMA-b-PVEAQ-SH): Synthesis and Applications in Drug Delivery1118930510.22034/jbr.2019.190491.1011ENAliyeh GhamkhariHalal Research Center of IRI, FDA, Tehran, IranFarideh MahmoodzadehHalal Research Center of IRI, FDA, Tehran, IranJournal Article20190617Theranostic nanoparticles with multifunctional ability have been emerging as a new platform for biomedical applications such as imaging, sensing and drug delivery. Despite gold nanorods (GNRs) being an excellent nanosource with multifunctional versatility, they have certain limitations in biomedical applications, which include surfactant toxicity, biological stability and controlled drug release kinetics. Hence, we fabricated thiol-end caped diblock copolymer [poly(2-hydroxyethyl methacrylate)-b-poly[(N-4-vinylbenzyl), N,N-diethylamine)]; [PHEMA-b-PVEA] encapsulated gold nanorods (GNRs) via RAFT polymerization techniques. pH responsive drug release ability of the synthesized biocompatible nanocomposite were also investigated .Also the success of coating was verified by fourier transform infrared (FTIR), zeta potential, transmission electron microscopy (TEM), dynamic light scattering (DLS), proton nuclear magnetic resonance (1H NMR) spectroscopies, gel permeation chromatography (GPC) analysis and UV-Vis spectroscopy. We developed a GNRs@copolymer as narnocarier by using MTX-loading and to enhanced pharmacokinetics. The anti-cancer drug (MTX) was encapsulated into the GNRs@copolymer by the electrostatic force. The MTX-encapsulation efficiency was calculated to be 97% . Release behaviors of MTX from the nanocomposite shown that the rate of MTX release could be controlled by pH value.https://www.journalbe.com/article_89305_3e4c3edc9794b9710095c0868ffd393a.pdfTissues and Biomaterial Research Group-(TBRG)Journal of Bioengineering Research2645-56331220190601An Isotropic Hyperelastic Model of Esophagus Tissue Layers along with three-dimensional Simulation of Esophageal Peristaltic Behavior12278930710.22034/jbr.2019.189018.1009ENPeiman HajHosseiniResearch Engineer;
Young Researchers and Elite Club
Central Tehran Branch, Islamic Azad University, Tehran, Iran0000-0001-6008-0856Meisam TakalloozadehAssistant Professor at Shiraz University0000-0003-1193-600XJournal Article20190607Understanding mechanical characterization of the esophagus tissue layers is a step forward to the development of esophageal behavior, peristaltic simulation, and advanced clinical practices. Esophagus tissue layers behave nonlinear with a large amount of malformation. In this paper, different models based on the hyperelastic theory are discussed and compared to investigate the accuracy of the simulations in esophagus tissue mechanics. The simulated tissues were assumed as nonlinear, incompressible, and homogenous isotropic material. We have used the least square method for the best curve-fitting materials corresponding to the Mooney-Rivlin, Ogden, and Neo Hookean models. The results show a perfect agreement with Ogden hyperelastic model compared to the experimental studies. Moreover, based on our results, we have developed the three-dimensional finite element (FE) models by simulation of esophageal dynamic movements. Hence, FE analyses are taken into account for both simplicity and simulation of esophageal peristaltic behavior. By the numerical solutions, an interactive coding between MATLAB and ABAQUS software have been developed to achieve our goal. Current investigation is an effort to simulate esophagus, which would be used as a predictable tool for the medical and physio-mechanical study as well as educational purposes.https://www.journalbe.com/article_89307_2724b10197c8323dab0b3b99ebbdb852.pdfTissues and Biomaterial Research Group-(TBRG)Journal of Bioengineering Research2645-56331220190701An Antibacterial Activity effect of a Novel AB Block Copolymer28358930810.22034/jbr.2019.190383.1010ENAliyeh GhamkhariInstitute of Polymeric Materials and Faculty of Polymer Engineering, Sahand University of Technology, Tabriz, IranHossein Samadi-KafilDrug Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranJournal Article20190616Various approaches are being developed for the explore of novel and powerful antimicrobial agents, in the form of synthetic polymeric.<br />Novel poly(2-hydroxyethyl methacrylate)-b-[(N-4-vinylbenzyl),N,N-diethylamine) PHEMA-b-PVEA diblock copolymer was prepared via reversible addition fragmentation transfer (RAFT) polymerization to investigate antibacterial behavior. The structure of the AB diblock copolymer was investigated by means of Fourier transform infrared (FTIR), and 1H nuclear magnetic resonance (NMR) spectroscopies. The molecular weights of PHEMA and PHEMA-b-PVEA segments were calculated to be 10300 and 24000 gmol-1 by GPC, respectively. Furthermore, the antibacterial activity was verified by selecting four types of antibacteria subsuming Staphylococcus aureus (S. aureus), Bacillus cereus (B. cereus), Candidaalbicans (C. albicans) and Escherichia coli (E. coli) as Gram-positive and Gram-negative bacteria models. Results exhibited remarkable fine antibacterial activity. High antibacterial activity effects were observed for C. albicans with PHEMA-b-PVEA diblock copolymers having 44, 75, and 90 mm diameter halo of bacterial inhibition. PHEMA-b-PVEA copolymers could be considered in nanoparticles and antibacterial applications due to their excellent behavior.https://www.journalbe.com/article_89308_ea95a9b0ba40a7d1e584840f7061a4d1.pdfTissues and Biomaterial Research Group-(TBRG)Journal of Bioengineering Research2645-56331220190601Stress Analysis of a Nature-Inspired Skin Adhesive Patch as a Wound Closure Technique36539217910.22034/jbr.2019.197960.1012ENHadi KhoramishadMechanical Engineering Faculty, Iran University of Science and TechnologyMohammad ArjomandiMechanical Engineering , Iran University of Science and TechnologyRomina ArjmandiMedical Science, Tehran University of Medical SciencesJournal Article20190813Skin is the outermost layer of human body that protects it from various threats. Although the human skin acts as a protective layer, when the skin is injured it can be an open inlet for bacterial and virus attacks. Staples and sutures are used to close the skin wounds but they cause some problems such as skin irritation. Utilizing adhesive patches can be considered as an appropriate alternative to the sutures and staples. In this paper, two natural mechanisms found in the gecko toe pad and housefly feet were employed in order to improve the skin adhesive patch performance. Finite element simulations were conducted in order to study the effects of different geometrical parameters of the skin adhesive patch and achieve better performance of the patch. The proposed configuration of the skin adhesive patch can completely close the wound opening and provide effective air circulation to aid cell and tissue regeneration. Therefore, it can provide better biocompatibility with the human skin in contrast with the traditional skin adhesive patches with minimal patient inconvenience.https://www.journalbe.com/article_92179_d3c5f09cd930c917aaad682025fa9d24.pdf