Contribution of the computational tools in understanding the blood rheology

Document Type : Review Article


1 Foothill College, Biological & Health Science Department, California, USA

2 Shiraz University of Medical Sciences, Shiraz, Iran

3 School of Paramedical Sciences, Bushehr University of Medical Science, Bushehr, Iran

4 Kazerun Islamic Azad University, Medical School, Kazerun, Iran



This article presents a literature review to evaluate the capabilities and limitations of available computational tools in studying the behavioral properties of blood flow in capillaries. PubMed, Embase, and Web of Science databases are explored for articles published on topics such as red blood cells, blood flow, non-Newtonian fluid field, and finite element analysis of biomedical devices. Recent advancements in the modeling of complex fluid fields help researchers better understand RBCs' different mechanisms and interactions in micro-capillaries. Hence, the characteristics of a single red blood cell in micro-capillaries is reviewed and discussed in this article. Such understanding could help us predict, manipulate and control the blood flow by changing the viscosity or interactions between different components. Moreover, computational tools provide a quantitative assessment of interactions between various components. While more research is required to fully understand the blood flow in veins & arteries, the presence of experimental studies is of paramount importance to verify and validate the current models.


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