Comparison of Serologic Celiac Disease in Patients with Hypothyroidism and Healthy Controls: A Case-Control Study

Document Type : Original Article


1 Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran

2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

3 Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4 Cancer Epidemiology Research and Treatment Center, Emam reza hospital, Tehran, Iran

5 Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

6 Colorectal research center, Shiraz University of Medical Sciences, Shiraz, Iran

7 Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran



Objectives: Celiac disease often accompanies by other endocrinologic diseases such as hypothyroidism. We aimed to determine the prevalence of celiac disease in autoimmune and non-autoimmune and clinical and subclinical hypothyroidism based on serological evaluation. Methods: This case-control study was conducted in a referral clinic of Kurdistan University of Medical Sciences, Sanandaj Iran. The case group was assigned as patients who had clinical and subclinical hypothyroidism (based on TSH levels), and the control group included patients without any thyroid or gastrointestinal problems. The levels of anti-tissue transglutaminase antibody (anti-TTG) were assessed in all case and control patients. Results: Two-hundred and fifty patients (150 in the control group) were included in the final analysis. The mean age of patients was 37.4 ± 10.4, and there were no significant differences for age and gender between the case and control groups (P-value > 0.05). The celiac serology was positive in five patients in the case group (5%) and two in the control group (1.3%). Celiac positive serology was significantly higher in the case group than the control group (P < 0.05). Conclusions: While undiagnosed and untreated CD causes comorbidities in hypothyroid patients, timely CD diagnosis and treatment diminishes the complications that were caused. Considering the significant relation and growing prevalence, it seems logical to design a screening program to detect CD in hypothyroid patients, especially the clinical ones with autoimmune hypothyroidism, especially those who require higher doses of levothyroxine.