An Antibacterial Activity effect of a Novel AB Block Copolymer

Document Type: Original Article


1 Institute of Polymeric Materials and Faculty of Polymer Engineering, Sahand University of Technology, Tabriz, Iran

2 Drug Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran



Various approaches are being developed for the explore of novel and powerful antimicrobial agents, in the form of synthetic polymeric.
Novel poly(2-hydroxyethyl methacrylate)-b-[(N-4-vinylbenzyl),N,N-diethylamine) PHEMA-b-PVEA diblock copolymer was prepared via reversible addition fragmentation transfer (RAFT) polymerization to investigate antibacterial behavior. The structure of the AB diblock copolymer was investigated by means of Fourier transform infrared (FTIR), and 1H nuclear magnetic resonance (NMR) spectroscopies. The molecular weights of PHEMA and PHEMA-b-PVEA segments were calculated to be 10300 and 24000 gmol-1 by GPC, respectively. Furthermore, the antibacterial activity was verified by selecting four types of antibacteria subsuming Staphylococcus aureus (S. aureus), Bacillus cereus (B. cereus), Candidaalbicans (C. albicans) and Escherichia coli (E. coli) as Gram-positive and Gram-negative bacteria models. Results exhibited remarkable fine antibacterial activity. High antibacterial activity effects were observed for C. albicans with PHEMA-b-PVEA diblock copolymers having 44, 75, and 90 mm diameter halo of bacterial inhibition. PHEMA-b-PVEA copolymers could be considered in nanoparticles and antibacterial applications due to their excellent behavior.

Graphical Abstract

An Antibacterial Activity effect of a Novel AB Block Copolymer


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